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Synthetic protein alignments by CCMgen quantify noise in residue-residue contact prediction
[article]
2018
bioRxiv
pre-print
Compensatory mutations between protein residues that are in physical contact with each other can manifest themselves as statistical couplings between the corresponding columns in a multiple sequence alignment (MSA) of the protein family. Conversely, high coupling coefficients predict residues contacts. Methods for de-novo protein structure prediction based on this approach are becoming increasingly reliable. Their main limitation is the strong systematic and statistical noise in the estimation
doi:10.1101/344333
fatcat:2sfeqkguo5h2pdxqsjwyarrnfe