Internet Archive Scholar

RENAL EXCRETION MECHANISM OF AT-2266 IN DOGS
AT-2266の腎排泄機序

KUNIHIKO TAKEYAMA, HISAO MINATO, NOBUUKI KUROBE, KANOO HOSOKI, TOSHIAKI KADOKAWA, KENJIRO YAMAMOTO
1984 Chemotherapy  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (590.6 kB)
https://web.archive.org/web/20220504042502/https://www.jstage.jst.go.jp/article/chemotherapy1953/32/Supplement3/32_Supplement3_154/_pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL. The file type is application/pdf.

Mechanism of renal excretion of AT-2266, a new chemotherapeutic agent, was investigated in anesthetized dogs using renal clearance and stop-flow methods. Results were compared with those of pipemidic acid. (1) Renal clearance rate of AT-2266 was lower than that of pipemidic acid. (2) AT-2266 differed from pipemidic acid in stop-flow study in which AT-2266 showed a similar pattern with creatinine. These results suggested that the renal excretion of AT-2266 took place mainly by glomerular
more » ... on. The longer biological half life time of AT-2266 than that of pipemidic acid might derive from the above characteristic in renal excretion.
doi:10.11250/chemotherapy1953.32.supplement3_154 fatcat:e6z3ot2e55bwfkrmm46xr7tu3q
lang:ja
Citation

KUNIHIKO TAKEYAMA, HISAO MINATO, NOBUUKI KUROBE, KANOO HOSOKI, TOSHIAKI KADOKAWA, KENJIRO YAMAMOTO. "RENAL EXCRETION MECHANISM OF AT-2266 IN DOGS." Chemotherapy 32.Supplement3 (1984) 154-158