Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis

Michael J. Brennan, Bartholt Clagett, Hillary Fitzgerald, Vicki Chen, Ann Williams, Angelo A. Izzo, Lewellys F. Barker
2012 Vaccine  
In this review, published peer-reviewed preclinical studies using prime-boost tuberculosis (TB) vaccine regimens in animal challenge models for tuberculosis have been evaluated. These studies have been divided into groups that describe prime-boost vaccine combinations that performed better than, equivalent to, or worse than the currently used BCG vaccine. Review of the data has revealed interesting findings, including that more than half of the published studies using BCG as a prime combined
more » ... h a novel boost vaccine give better efficacy than BCG alone and that the greatest reduction in Mycobacterium tuberculosis (M.tb.) colonization of animal tissues is provided by viral vectored vaccines delivered intranasally. Careful evaluation of these data should assist in defining the value of prime-boost regimens for advancement into human TB vaccine trials and stimulate the development of criteria for choosing which vaccine candidates should be studied further.
doi:10.1016/j.vaccine.2012.02.036 pmid:22387630 pmcid:PMC3335191 fatcat:ggfaor3fwnd6na2kiegowzx3ty