TOXICODYNAMICS PECULIARITIES AND RISK ASSESSMENT OF NEW MICROSOMAL ENZYMES INDUCTOR FUNGICIDE SEDAXANE

A.M. Antonenko
2016 Ukraïnsʹkij naukovo-medičnij molodìžnij žurnal  
Summary. It is known that today from crop diseases dying about a third of the crop. Furthermore, fungal toxins can cause poisoning of humans and animals. For combating these problems pesticides are widely used. One of the way of solving the problem of pest resistance to commonly used fungicides is the use of substances with a novel mechanism of action, such as a promising class of fungicides succinate dehydrogenase inhibitors. The aim of the work was hygienic risk assessment on toxicological
more » ... teria of the new fungicide inhibitor of succinate dehydrogenase II generation sedaxan, scientific substantiation of its acceptable daily intake. Assessment of toxicity to warm-blooded laboratory animals and the danger to humans was carried out by the literature and websites according to the current in Ukraine hygienic classification of pesticides by hazard (DSanPin 8.8.1.002-98). Acceptable daily dose of sedaxane for humans substantiated according to the methodology of integrated hygienic regulation of pesticides, adopted in Ukraine. The toxicodynamics peculiarities of new fungicides sedaxane were studied. It was found that in accordance with hygienic classification of pesticides it is referred to the 3rd class of hazard (moderately hazardous). It was shown that the primary target organ of sedaxane action is liver, secondary - thyroid gland. It was established that sedaxan is microsomal enzyme inducer of phenobarbital type. Acceptable daily dose for humans of sedaxane was substantiate on level of 0,1 mg/kg.
doi:10.32345/usmyj.1(93)().2016.6-9 fatcat:26l3vyyfynenvbvml2uqohlp3i