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Autoimmune antibodies to ␤ 2 -glycoprotein I (␤2GPI) have been proposed to be clinically relevant because of their strong association with thrombosis, miscarriage, and thrombocytopenia. By using a homologous recombination approach, ␤2GPI-null mice were generated to begin to understand the physiologic and pathologic role of this prominent plasma protein in mammals. When ␤2GPI heterozygotes on a 129/Sv/C57BL/6 mixed genetic background were intercrossed, only 8.9% of the resulting 336 offspringdoi:10.1074/jbc.m010990200 pmid:11145969 fatcat:2fxqdqecvfeefdwfo74xyxvyai