Liver disease is one of the primary causes of morbidity and mortality among human immunodeficiency virus (HIV) infected patients. These HIV patients are at risk of liver fibrosis. Diagnose of liver fibrosis using noninvasive markers among HIV infected people in sub-Saharan Africa including Ethiopia are not widely used in order to perceive patient outcome. Method: A hospital based cross sectional study was conducted at Zewditu Memorial Hospital. Participants' sociodemographic and clinical

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... tion were collected from the Anti-Retroviral Therapy (ART) database. Blood samples were collected from 195 volunteer, patients taking HAART for at least 1 year. The APRI score were used to determine the presence of significant fibrosis. Data was entered and analyzed by SPSS version 20 and p value less than 0.05 was taken as statistically significant. Result: Of the 195 participants, majority of study participants were in age group 30-39 (45.12%), female (57.43%) and they were married (49.22%).Overall burden of liver fibrosis by APRI index was 4.09%. On the multivariate analysis after adjusting for age, CD4, WHO staging, BMI, being male (adjusted odds ratio = 0.122; 95% CI: 0.017-0.883) were significantly associated factors of liver fibrosis as measured by APRI. Conclusion: Significant fibrosis by APRI score was found in 4.09% among of HIV mono-infected patients. Male sex was associated with significant fibrosis. Further studies shall be conducted to consolidate these study findings.