ASSESSMENT OF CAROTID ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS IN ASIAN INDIAN COHORT: A CROSS-SECTIONAL STUDY
Journal of Evolution of Medical and Dental Sciences
BACKGROUND Rheumatoid arthritis is a multisystem disease. Extra-articular manifestations add to morbidity and are the main cause of mortality in Rheumatoid Arthritis. Cardiovascular disease in Rheumatoid arthritis is the main contributor to increase morbidity and mortality in RA and is associated with premature atherosclerosis. AIM AND OBJECTIVE Study the incidence or occurrence of carotid atherosclerosis in Rheumatoid Arthritis and its correlation with inflammatory markers and activity of the
... nd activity of the disease in Asian Indian cohort. METHOD AND MATERIAL A total of 60 cases were enrolled in the study after obtaining informed written consent, of which 30 were RA patients fulfilling the ACR 1987 criteria for Rheumatoid arthritis and 30 were matched, healthy control. Measuring the Intima-Media Thickness (IMT) of the carotid artery bifurcation with ultrasonogram Doppler using a high resolution 7.5 -MHz linear transducer. RESULTS Mean age of patients with Rheumatoid arthritis was 42.69±14.89 years, while that of controls was 41.17±12.01 years (p -0.81). Carotid Intima-Media Thickness was significantly higher (0.626±0.124 Vs 0.455±0.057; P < 0.0001) in RA patients as compared to the control group. CONCLUSION Patients with rheumatoid arthritis have a marked increase in carotid atherosclerosis and carotid -IMT independent of traditional risk factors including age.