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Interaction of the Disordered Yersinia Effector Protein YopE with Its Cognate Chaperone SycE
2009
Biochemistry
We describe an efficient approach to model the binding interaction of the disordered effector protein to its cognate chaperone in the type III secretion system (T3SS). Starting from de novo models, we generated ensembles of unfolded conformations of the Yersinia effector YopE using REMD simulations and docked them to the chaperone SycE using a multistep protein docking strategy. The predicted YopE/SycE complex was in good agreement with the experimental structure. The ability of our
doi:10.1021/bi9017347
pmid:19877667
fatcat:r5ufrs6ic5bzpoltrzu7ez4r6i