Monitoring Progressive Multiple Sclerosis with Novel Imaging Techniques

Maria Petracca, Monica Margoni, Giulia Bommarito, Matilde Inglese
2018 Neurology and Therapy  
Imaging markers for monitoring disease progression in progressive multiple sclerosis (PMS) are scarce, thereby limiting the possibility to monitor disease evolution and to test effective treatments in clinical trials. Advanced imaging techniques that have the advantage of metrics with increased sensitivity to short-term tissue changes and increased specificity to the structural abnormalities characteristic of PMS have recently been applied in clinical trials of PMS. In this review, we (1)
more » ... e an overview of the pathological features of PMS, (2) summarize the findings of research and clinical trials conducted in PMS which have applied conventional and advanced magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques.
doi:10.1007/s40120-018-0103-2 pmid:29956263 pmcid:PMC6283788 fatcat:5atggmvtjredddx237lqlkwejq