Novel chemico-mechanical approach towards long-term implantable glucose sensing

Christophe Boss, Eric Meurville, Jean-Michel Sallese, Peter Ryser
2009 Procedia Chemistry  
The proof of concept of a continuously sensing affinity device based on the glucose-dependent viscosity of a sensitive solution containing dextran and Concanavalin A has been successfully demonstrated. The biosensor incorporates a piezoelectric diaphragm and a flow-resisting microchannel for viscosity detection, and a free-standing Anodic Alumina Oxide (AAO) porous nano-membrane as glucose selective interface. Extensive in vitro glucose measurements between two physiologically relevant glucose
more » ... oncentrations, 2 mM and 9 mM (respectively hypo-and hyperglycemia), were successfully performed during 4 days. To the best of our knowledge, such reversibility and stability of glucose measurement over time had not been reported yet.
doi:10.1016/j.proche.2009.07.078 fatcat:uxde2t3n2fczdo3ya27ahxg3am