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Insulin resistance plays a major role in the pathogenesis of type 2 diabetes, yet despite much research the underlying mechanism responsible for it is poorly understood. In this review, some recent advances in the understanding of insulin resistance in humans that have been made by using magnetic resonance spectroscopy are discussed.doi:10.1152/physiol.00007.2004 pmid:15304632 fatcat:su3gpp77szhetomp26xvx22ztu