Impact of Bedaquiline on Multidrug-Resistant Tuberculosis Treatment to Mother and Baby: An Incidental Case

2021 Indian Journal of Forensic Medicine & Toxicology  
Bedaquiline is a new drug which is recommended by World Health Organization (WHO) for individual regiment drug resistant-tuberculosis (DR-TB). The presence of regiment DR-TB in the blood is long enough with T 1/2 5-6 months, that is why bedaquiline is given on six months. Bedaquiline is not recommended for pregnant women because there is no data related to safety. The author will report an incidental pregnant female on bedaquiline treatment. Case presentation: A 24-year-old woman with multidrug
more » ... oman with multidrug resistant tuberculosis (MDR TB) on individual regiment bedaquiline had incidental pregnancy at the 6 th month treatment. In the beginning, the patient used bedaquiline because of the intolerance of second-line injectable drug. Bedaquiline regiment was used for 24 th week. Pregnancy occured at the 6 th month treatment. The patient continued the pregnancy and the MDR TB treatment was continued without bedaquiline. Nausea and vomiting were getting worse. Preterm labour occured in 33/34 weeks by cesarean section. The baby had severe asphyxia, used continuous positive airway pressure (CPAP), treated in NICU, had low weight but there was no disability. After several days of treatment, the condition of baby was improving and was able to outpatient. Conclusion: The preterm labour, low birth weight, and neonatal emergency occured in a pregnant woman with MDR TB on individual regiment bedaquiline. Mother and baby can survive. More case and research data are needed on the safety of bedaquiline during pregnancy.
doi:10.37506/ijfmt.v15i1.13669 fatcat:wtgi3jrkb5fbtpfwuiub7ooqtu