Potential role of interferon-lambda in the treatment of inflammation and cancer: an update

Markus Neurath, Heike Dornhoff, Juergen Siebler
2011 International Journal of Interferon Cytokine and Mediator Research  
The interferon (IFN) family comprises various cytokines with potent responses against RNA and DNA viruses as well as antitumor activities. A recently identified interferon subgroup consists of the so-called lambda interferons with several members, including IFN-λ1, IFN-λ2, and IFN-λ3 (also denoted interleukin [IL]-29, IL28-A, and IL28-B). They represent a newly identified group of the class II cytokine family. While they are functionally related to type I IFNs, they are structurally related to
more » ... turally related to the IL-10 cytokine family. The lambda IFNs signal through a cytokine receptor complex which is unique for IL-28 and IL-29, designated IL-28Rα, and a second chain, the IL-10R2, which is shared with receptors for IL-10 related cytokines such as IL-22 and IL-10. In this review, we summarize recent findings about the relationship between type I and type III IFN signaling as well as their antiviral and antitumor activity. A better understanding of the functional role of IFN-λ in viral infections and immune responses in innate and adaptive immunity opens new therapeutical approaches for the treatment of chronic inflammatory diseases and cancer.
doi:10.2147/ijicmr.s15249 fatcat:vwexytex6rdphnecttwn5zvfna