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Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces
2010
BMC Bioinformatics
Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides insight into the protein's mechanism, can aid the design of further experiments, and eventually can lead to the development of new medicines and diagnostic tools. Results: In this article we describe HOPE, a fully automatic program that analyzes the structural and functional effects of point mutations. HOPE collects information from a
doi:10.1186/1471-2105-11-548
pmid:21059217
pmcid:PMC2992548
fatcat:q7kl7g3c7je6fl7o7ftmpoir7i