We apply the method of penalization to the Dirichlet problem for the Navier-Stokes-Fourier system governing the motion of a general viscous compressible fluid confined to a bounded Lipschitz domain. The physical domain is embedded into a large cube on which the periodic boundary conditions are imposed. The original boundary conditions are enforced through a singular friction term in the momentum equation and a heat source/sink term in the internal energy balance. The solutions of the penalized

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... roblem are shown to converge to the solution of the limit problem. Numerical experiments are performed to illustrate the efficiency of the method.