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Lipid droplet structural remodeling in adipose tissue upon caloric excess
[article]
2021
bioRxiv
pre-print
Excess calories are stored as triacylglycerols (TAG) and cholesteryl esters (CE) in lipid droplets (LD), and during obesity, LD expansion occurs. X-ray scattering of adipose tissue uncovered that LDs comprise two TAG packing domains: a disordered core and a multilamellar shell. The number of TAG layers increases upon diet-induced obesity and is adipose depot-specific. Further, collagen was highly oriented in brown but randomly dispersed in white fat. We discovered that the body's surfactant,
doi:10.1101/2021.08.23.457409
fatcat:smsdzhq6lbdf5cb7iwk2a6sgqy