Abstract: Pain control in musculoskeletal disorders is still a challenging task. The most effective treatment of pain in autoimmune and immune-mediated diseases is the treatment of the disease itself. Analgesics, non-steroidal anti-inflammatory drugs and opioids are used to relieve pain. Analgesia is the central intervention of degenerative disorders. The most effective analgesic compounds are the non-steroidal anti-inflammatory drugs (NSAIDs). Concerns are raised regarding the safety of

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... There is not any organ which is not involved in adverse reactions, but the damage of the gastrointestinal system has been considered the most serious one for a long time. In the 21st century, the recognition of cardiovascular complications led to the re-evaluation of the role of these drugs in analgesia. Orv Hetil. 2019; 160(22): 855–860.