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Computer-aided Validation of Fluorobenzimidazole as Soluble Epoxide Hydrolase Inhibitor: An In-Silico Study
Pharmaceutical and Biosciences Journal
Soluble epoxide hydrolase (sEH) is an enzyme and is encoded by the gene EPHX2 in human beings. Indeed, by inhibiting the biotransformation of these epoxide(s) via arresting the action of the mammalian sEH one can develop a promising antihypertensive drug(s). The present work was emphasized the possible binding mode of fifteen fluorobenzimidazole (4a-4o) derivatives as soluble epoxide hydrolase (sEH) inhibitors. The X-ray crystal structure of human sEH in complex with the inhibitor 6NJdoi:10.20510/pbj/9/i2/1487 fatcat:udzy45mid5hr3fnosjpmamzy7e