EFfect Of Platelet Aggregation Inhibitor On Foetal Outcome In Cases Of Eph Gestosis

N Bhattacharya, S Bhattacharya, K Mukherjee, N Bose, B Das, T Chakravorti, P Pradhan, B Samanta
1981 Thrombosis and Haemostasis  
42 mothers with clinical features of mild to moderate specific gestosis (Oedema, Proteinuria, Hypertension) with mean age 29.6±2.8 yrs SD, mean diastolic pressure at 28 weeks 98±4.4, mean parity 2.1±1.1, were enrolled in a placebo controlled double blind trial to see the effect of Dipyridamole (a platelet aggregation inhibitor mainly) in 100 mg t.i.d. on the augmentation of the placental perfusion, by changing the microplatelet thrombi, from 28 weeks up to term. Mothers randomized and grouped
more » ... ually. Group A received placebo and Group B received drugs in the schedule mentioned. Two cases started premature labour (Group A) and excluded from study. The mean foetal wt in Group B 2700±67 and in Group A 2462±142, expressed in Gms with SD. Fibrinoid area stained with Phosphotungstic acid Aniline Blue of Mallory, was estimated for point counting of W. Ahere (The Placenta, pp. 83-84, Ed. P. Gruenwald, MTP, 1975). The result of the counting suggested a positive physiological correlationship with the outcome of the foetal weight in this tentative study.
doi:10.1055/s-0038-1653390 fatcat:2orebozoibebjb55v5mqjodwmu