Triacylglyceride physiology in the short-finned eel, Anguilla australis—the effects of androgen

Erin L. Damsteegt, Yuichi Ozaki, Sally P. A. McCormick, P. Mark Lokman
2016 American Journal of Physiology. Regulatory Integrative and Comparative Physiology  
The importance of androgens (especially 11-ketotestosterone) during previtellogenesis in eels is well established. In wild pubertal migrants, circulating 11-ketotestosterone levels correlate with a number of morphological and molecular changes. Here, we test the prediction that this correlation represents a causal relationship by artificially raising the levels of circulating 11-ketotestosterone in prepubertal nonmigratory female and pubertal, migratory male short-finned eels (Anguilla
more » ... ) using sustainedrelease hormone implants. In females, increases in hepatosomatic index and transcript copy numbers of hepatic apolipoprotein B and microsomal triacylglyceride transfer protein indicated increased repackaging of endogenously sourced triacylglycerides. These changes in liver measures were reflected in increased concentrations of serum triacylglycerides. However, despite a small increase in gonadosomatic index, ovarian lipoprotein receptor transcript abundances were not affected by 11-ketotestosterone. Interestingly, no such changes in hepatic gene expression were detected in a dose-response experiment using males. We propose that the androgens are inducing the observed changes in previtellogenic females, although it remains unclear to what extent these effects are direct or indirect.
doi:10.1152/ajpregu.00149.2015 pmid:26764051 fatcat:wuemnehfyjhmtc4a7uvsbsa57u