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4-Hydroxy-2-hexenal-induced apoptosis in human renal proximal tubular epithelial cells
Nephrology, Dialysis and Transplantation
Background. The aldehyde products of lipid peroxidation such as 4-hydroxy-2-hexenal (HHE) might be responsible for the pathogenesis of kidney injury. The present study was aimed to investigate the effects of HHE on renal tubular epithelial cells and its signaling mechanisms. Methods. Human proximal tubular epithelial (HK-2) cells were treated with 10 lM of HHE. Cell viability was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The fluorescent probedoi:10.1093/ndt/gfr386 pmid:21771752 fatcat:ntnbno7vgjh73a2lc7x325efze