The change of serum leptin and its soluble receptor in patients with gestational diabetes mellitus as well as their correlation with insulin resistance and inflammatory response

Yi Xiao1, Cai-Xuan Tian2, Yu Wang1, Qing He1
2017 Journal of Hainan Medical University  
Objective: To study the change of serum leptin and its soluble receptor in patients with gestational diabetes mellitus (GDM) as well as their correlation with insulin resistance and inflammatory response. Methods: A total of 118 patients with GDM who delivered in our hospital between June 2014 and November 2016 were collected as observation group, and 60 puerperae with normal glucose metabolism who delivered in our hospital during the same period were collected as normal control group. Before
more » ... rol group. Before delivery, the contents of Leptin and its soluble receptor in serum, the levels of insulin resistance indexes in peripheral blood and the contents of inflammation indexes in serum and placental tissue of two groups of puerperae were determined, and Pearson test was used to further evaluate the correlation of serum Leptin and SLR levels with insulin resistance and inflammatory response in patients with GDM. Results: Serum Leptin content of observation group was higher than that of normal control group while SLR content was lower than that of normal control group; insulin resistance indexes FINS and HOMA-IR levels in peripheral blood were significantly higher than those of normal control group while HOMA-β level was lower than that of normal control group; inflammatory response indexes IL-1β, IL-2 and IL-6 contents in serum and placental tissue were significantly higher than those of normal control group. Pearson test showed that serum Leptin and SLR levels in patients with GDM were directly correlated with the degree of insulin resistance and inflammatory response. Conclusions: Serum Leptin and SLR expression are abnormal in patients with GDM and the abnormal degree is directly correlated with the degree of insulin resistance and inflammatory response.
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