Harmonic analysis on Hermitian symmetric spaces of tube type is a natural framework for introducing multivariate Meixner-Pollaczek polynomials. Their main properties are established in this setting: orthogonality, generating and determinantal formulae, difference equations. For proving these properties we use the composition of the following transformations: Cayley transform, Laplace transform, and spherical Fourier transform associated to Hermitian symmetric spaces of tube type. In particular

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... he difference equation for the multivariate Meixner-Pollaczek polynomials is obtained from an Euler type equation on a bounded symmetric domain.