Epidemiology of Guillain-Barré Syndrome in the Province of Quebec

Geneviève Deceuninck, Renée-Myriam Boucher, Philippe De Wals, Manale Ouakki
2008 Canadian Journal of Neurological Sciences  
Background:In the province of Quebec, a population-based study of Guillain-Barré syndrome (GBS) was conducted at the time of a mass immunization campaign against meningococcal disease, in 2001.Methods:The study population included residents aged 2 months to 20 years observed from November 1st, 2000 to December 31, 2002, representing 4 075 465 person-years of observation. GBS cases were identified in the provincial hospital database Med-Echo and medical records were reviewed.Results:Thirty-three
more » ... incident GBS cases were identified, including 27 cases of acute inflammatory demyelinating polyradiculopathy. The overall GBS incidence rate was 0.8/100 000 person-years, higher in persons aged 1 to 4 years (2.1/100 000) than in those 5 years or more (0.6/100 000). There was a female preponderance and no significant seasonal variation. All patients survived.Conclusion:Results could be used to interpret reports of adverse events associated with the introduction of new vaccines in this age-group in Canada.
doi:10.1017/s0317167100009136 fatcat:xcxuhfakgnbv3ldbgvskjcsuu4