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Preconditioning with morphine protects hippocampal CA1 neurons from ischemia–reperfusion injury via activation of the mTOR pathway
Canadian Journal of Physiology and Pharmacology
The signaling pathway of chronic morphine treatment to prevent neuronal damage following transient cerebral ischemia is not clear. In the present study, we examined the role of mammalian target of rapamycin (mTOR) to reveal the neuroprotective effects of chronic morphine preconditioning on the hippocampus following ischemia/reperfusion (I/R) injury. Morphine was administrated for 5 days twice a day before I/R injury induction. The possible role of mTOR was evaluated by the injection ofdoi:10.1139/cjpp-2017-0245 pmid:28881154 fatcat:vkufebyazvdmvg6x752guatrpu