Dengue Fever Associated Liver Failure

Joanne Mui Ching Tan, Natalie Woon Hui Tan, Koh Cheng Thoon, Chia Yin Chong, Christina Ong
2016 Pediatric Infectious Diseases Open Access  
Dengue fever is common in Southeast Asia although liver failure is a rare complication with up to 50% mortality rate reported in children. Objective: To evaluate the characteristics and treatment outcome of dengue fever associated liver failure (DFALF) in a case series of 4 paediatric patients. DFALF was defined as INR>2, regardless of the presence or absence of encephalopathy or INR>1.5 not corrected by Vitamin K in the presence of clinical hepatic encephalopathy, during the course of
more » ... course of concurrent dengue infection. Material and methods: Patients with DFALF, admitted to a tertiary paediatric centre in Singapore over a 6 year period (January 2009-December 2015 were identified from the Gastroenterology and Infectious Disease databases. Case records were retrospectively reviewed.
doi:10.21767/2573-0282.100031 fatcat:rz537fxuazc7tgdpiefory3tua