Lactamization of Alkenyl C-H Bonds to Generate 2-Quinolinones with Triphosgene

Zhen Zhang, Guizhi Du, Zixiao Wang
2020 Heterocycles  
A simple and easy-going method is developed to synthesize the analogues of 2-quinolinones by using triphosgene (BTC) as the carbonyl source. In these reactions, both the toxic carbon monoxide (CO) and phosgene are avoided and the 2-quinolinones are obtained in moderate to good yields under mild conditions, all of which are anticipated to be meaningful in both industry and laboratory.
doi:10.3987/com-20-14232 fatcat:b47scbeok5br7mfdbg673ufksq