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DIPEPTIDYL PEPTIDASE-IV (DPP-IV) INHIBITORY ACTIVITY OF METFORMIN
2008
Pharmacologyonline
unpublished
Dipeptidyl peptidase IV is plasma membrane glycoprotein exopeptidase, inhibition of DPP-IV activity could be a useful strategy to enhance the activity of GLP-1. GLP-1 is an incretin released from L cells in the intestine after oral ingestion of nutrients. GLP-1 (7-37) is actively being evaluated as a therapy for diabetes mellitus. Metformin is an oral biguanide agent used for the treatment of type 2 diabetes. Male Wistar rats were used for the study. Serum glucose and DPP-IV levels (0 day) were
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