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The dynamics of biological processes are often modeled as systems of nonlinear ordinary differential equations (ODE). An important feature of nonlinear ODEs is that seemingly minor changes in initial conditions or parameters can lead to radically different behaviors. This is problematic because in general it is never possible to know/measure the precise state of any biological system due to measurement errors. The parameter synthesis problem is to identify sets of parameters (including initialdoi:10.1089/cmb.2009.0172 pmid:20377448 fatcat:eyr6ktislrfazcz2qgr6cd7qey