Isolation and Structure Determination of Metabolites from Cultures of Aspergillus protuberus
Aspergillus protuberus 배양물로부터 대사체 분리 및 구조 결정

So Yoon Baek, Sang Hee Shim
2013 The Korean Journal of Microbiology  
Marine-derived microbes have yielded a variety of metabolites so far. In the course of the project to find metabolites from marine microbes, an isolate of Aspergillus protuberus (SF 5767) was selected for chemical investigation. A large scale culture of this strain in PDA media was extracted with an organic solvent and the extract was fractionated by silica gel column chromatography. Repeated reverse phase HPLC of the fractions led to the isolation of three metabolites. Their chemical
more » ... were elucidated as deoxybrevianamide E (1), brevianamide V (2), and ergosterol peroxide (3) on the basis of spectroscopic data including MS, NMR, and UV. To the best of our knowledge, chemical investigation of A. protuberus was conducted for the first time in this study.
doi:10.7845/kjm.2013.3026 fatcat:j3jsozlgeba5tdnhs56iaotp7u