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Cellular responses often involve a transition of cells from one state to another. A transition from a stem cell to differentiated cell state, for example, may occur in response to gene expression changes induced by a transcription factor, or signaling cascades triggered by a hormone or pathogen. Regulatory networks are thought to control such cellular transitions. Thus, many researchers are interested in reconstructing regulatory networks, not only to gain a deeper understanding of cellulardoi:10.1016/j.tcb.2011.05.001 pmid:21632251 pmcid:PMC3149721 fatcat:7bi7tdqt2rhtzdzo2r7jlyt6cm