Current applications and future prospects of stem cells in dentistry

Sharmila Surendran, Gautham Sivamurthy
2015 Dental Update  
Stem cells are defined as clonogenic, unspecialized cells capable of both self-renewal and multi-lineage differentiation, contributing to regenerating specific tissues. For years, restorative treatments have exploited the lifelong regenerative potential of dental pulp stem cells to give rise to tertiary dentine, which is therapeutically employed for direct and indirect pulp capping. Current applications of stem cells in endodontic research have revealed their potential to continue root
more » ... tinue root development in necrotic immature teeth and transplanted/replanted teeth. Successful application of pulp revascularization is highlighted here with support of a clinical case report. This article also discusses the role of dental stem cells as a promising tool for regeneration of individual tissue types like dentine, pulp and even an entire functional tooth. CPD/Clinical Relevance: This article will help practising dental surgeons understand the significance of stem cells in dentistry. Clinicians can harness the potential of stem cells using procedures like pulp regeneration/revascularization in endodontics and improve their knowledge on the recent advances in tissue engineering and future applications of dental-derived stem cells.
doi:10.12968/denu.2015.42.6.556 pmid:26506811 fatcat:bjhz34vaprc4lp3n3rifhd3efq