Mammographic Changes in Postmenopausal Women: Comparative Effects between Continuous Combined Hormone and Single Estrogen Replacement Therapy

Sug Oh, Jong Tae Choi, Kyoon Soon Jung, Seung Hye Jung
1997 Journal of the Korean Radiological Society  
Purpose : As the use of hormone replacement therapy for the menopausal women increases, some caution is advised, since there is an increased risk ofbreast cancer. Accordingly, the importance of regular mammography has been addressed. This cross-sectional study analyzed the effects of different hormone therapies on mammographic density. Materials and Methods: Sixty-seven postemenopausal women who had completed one year ofhormone therapy and had undergone follow-up mammography, were divided into
more » ... wo groups: Group 1 : continuous conjugated equine estrogen, O. 625mg, plus continuous medroxyprogesterone acetate, 2.5mg (n=48), Group II : continuous conjugated equine estrogen 0.625 mg (n = 19). The mammograms were read by two radiologists. Res비 ts : With regard to the radiologists involved, interobserver reliability (kappa) was 0.70 and intrao bserver reliability (kappa) was 0.51 and 0.67 . Before hormone therapy, factors related to decreased mammographic density were age and number of full term pregnancies (p < 0.05) . After one year ofhormone therapy, body fat showed a significant increase (p < 0.05), but in spite of this, increased mammographic density induced by hormone therapy remained significantly high (p < 0.05). Compared with Group II , Group 1 showed a significant increase in mammographic density (p < 0 .05).
doi:10.3348/jkrs.1997.36.6.1087 fatcat:ojpavzpnfzg53gpam5bd65y7q4