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This study addresses four domains: 1) description of Role Playing learning model use as a learning strategy in Biology instructional process at school, 2) perspectives and threats obtained by teachers at school when addressing Protein Synthesis topic 3) Role Playing learning model in Protein Synthesis topic of Biology learning, 4) the influence of Role Playing learning model towards motivation and Biology learning outcome. The results of this study is teacher needs analysis instruments,doi:10.22437/bio.v4i1.5503 fatcat:bbvbb7nqwnacpmaqvoq7h5s3nm