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Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals
[article]
2020
bioRxiv
pre-print
Non-additive genetic variance for complex traits is traditionally estimated from data on relatives. It is notoriously difficult to estimate without bias in non-laboratory species, including humans, because of possible confounding with environmental covariance among relatives. In principle, non-additive variance attributable to common DNA variants can be estimated from a random sample of unrelated individuals with genome-wide SNP data. Here, we jointly estimate the proportion of variance
doi:10.1101/2020.11.09.375501
fatcat:estayqwia5faxa22dgucjnzvwu