Aim: Reviewing the existed literature that addresses the factors influencing adolescent's substance use disorder. Background: Substance use disorder among adolescents considered a major problem worldwide that affects adolescents wellbeing and destroys their functionality socially, physically and psychologically. Data Sources: A review of relevant literature uses electronic databases including EBSCO, MEDLINE, CINAHL, and PubMed. Methods: Using an integrative method, peer-reviewed research and

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... cussion papers published between 2011 and 2019 and listed in the CINAHL, SCOPUS, Science Direct, PubMed and Google Scholar databases were reviewed. Findings: A final review of 9 studies that used quantitative and qualitative research methods to study many factors was related to the substance use disorder. Themes were: Influence of psychological factors on adolescents. Influence of socio-cultural factors on adolescents, the influence of biological factors on adolescents and the influence of environmental factors on adolescents. Conclusions: Reviewed articles revealed that many psychological, biological, socio-cultural, and environmental factors that increase adolescents risk having substance use disorder. For example, stressful life events during adolescents like loss of someone increase the risk to take illicit substances in order to forget painful memory; personal tendency like curiosity and experimentation, increase the risk to have risk health behaviors like substance use disorder. Furthermore, adolescence is a critical period that youth need more supervision and health education to protect them from Substance use disorder.