Influenza virus–host interactomes as a basis for antiviral drug development

Tokiko Watanabe, Yoshihiro Kawaoka
2015 Current Opinion in Virology  
22 Currently, antiviral drugs that target specific viral protein functions are available for 23 the treatment of influenza; however, concern regarding the emergence of drug-24 resistant viruses is warranted, as is the urgent need for new antiviral targets, including 25 non-viral targets, such as host cellular factors. Viruses rely on host cellular functions 26 to replicate, and therefore a thorough understanding of the roles of virus-host 27 interactions during influenza virus replication is
more » ... ential to develop novel anti-28 influenza drugs that target the host factors involved in virus replication. Here, we 29 review recent studies that used several approaches to identify host factors involved in 30 influenza virus replication. These studies have permitted the construction of an 31 interactome map of virus-host interactions in the influenza virus life cycle, clarifying 32 the entire life cycle of this virus and accelerating the development of new antiviral 33 drugs with a low propensity for the development of resistance. 34 35 36 37
doi:10.1016/j.coviro.2015.08.008 pmid:26364134 pmcid:PMC5380926 fatcat:2bu4ako7qzdmzicoym5tf7ahde