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The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics
2020
Frontiers in Chemistry
Opioid receptors that belong to class A G protein-coupled receptors (GPCRs) are vital in pain control. In the past few years, published high-resolution crystal structures of opioid receptor laid a solid basis for both experimental and computational studies. Computer-aided drug design (CADD) has been established as a powerful tool for discovering novel lead compounds and for understanding activation mechanism of target receptors. Herein, we reviewed the computational-guided studies on opioid
doi:10.3389/fchem.2020.00335
pmid:32500054
pmcid:PMC7242749
fatcat:aohqt6wzsjap3n4wrnkrwkegty