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Understanding the effects of genetic variation is a fundamental problem in biology that requires methods to analyse both physical and functional consequences of sequence changes at systems-wide and mechanistic scales. To achieve a systems view, protein interaction networks map which proteins physically interact, while genetic interaction networks inform on the phenotypic consequences of perturbing these protein interactions. Until recently, understanding the molecular mechanisms that underliedoi:10.1038/s41576-021-00441-w pmid:35013567 pmcid:PMC8744059 fatcat:2gfcfglldzgofld7glzd2hqh6m