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MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles [article]

Lizhi He, Mingshi Gao, Henry Pratt, Zhiping Weng, Kevin Struhl
2022 bioRxiv   pre-print

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MafB (a bZIP transcription factor), ß-catenin (the ultimate target of the Wnt signal transduction pathway that acts as a transcriptional co-activator of LEF/TCF proteins), and WDR77 (a transcriptional co-activator of multiple hormone receptors) are important for breast cellular transformation. Unexpectedly, these proteins interact directly with each other, and they have similar genomic binding profiles. Furthermore, while some of these common target sites coincide with those bound by LEF/TCF,
more » ... e majority are located just downstream of transcription initiation sites at a position near paused RNA polymerase (Pol II) and the +1 nucleosome. Occupancy levels of these factors at these promoter-proximal sites are strongly correlated with the level of paused Pol II and transcriptional activity.
doi:10.1101/2022.02.17.480948 fatcat:hrs2csdav5gy5ngevoscbvewva
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Lizhi He, Mingshi Gao, Henry Pratt, Zhiping Weng, Kevin Struhl. "MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles." bioRxiv (2022)