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Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging
1998
FEBS Letters
Cell protection from stresses by the major heat shock protein Hsp72 was previously attributed to its ability to prevent aggregation and to accelerate refolding of damaged proteins. This repair function of Hsp72 may play an important role in cell survival after extremely harsh protein damaging treatments leading to necrotic cell death. On the other hand, protein repair function of Hsp72 cannot explain how it protects cells from stresses which do not cause direct protein damage, e.g. some
doi:10.1016/s0014-5793(98)01242-3
pmid:9821948
fatcat:6llde26jjvf5lcvpgjjkvrljvm