Asthma and Inflammation

Adrian Kwok Wai Chan
2019 The Singapore family physician  
Asthma is a chronic inflammatory airway disease, for which the cornerstone of asthma therapy is inhaled corticosteroids. however, long term clinical outcomes are variable, and not all patients respond optimally to corticosteroids. Underpinning this observation is that asthma is a heterogeneous disease consisting of phenotypes that are driven by different inflammatory pathways. In this article, we will discuss the different inflammatory mechanisms of asthma to better define patient
more » ... tient characteristics and help improve patient outcomes with newer specific-targeted asthma therapies. Sfp2019; 45(6) : 5-6 14 Cox C, Kjarsgaard M, Surette MG, Cox PG, Nair P. A multidimensional approach to the management of severe asthma: Inflammometry, molecular microbiology and bronchial thermoplasty. • Asthma is a heterogeneous disease characterised by different inflammatory mechanisms. • Asthma can be broadly classified into T2-high asthma and T2-low asthma. However, with a greater understanding of biologic pathways and the immune cells involved, the aim is to accurately characterise asthma characteristics and lead to targeted therapeutic approaches. • Patients with T2-high asthma are more likely to be corticosteroid responsive and may benefit from newer biologic therapy. In contrast, T2-low asthma tends to demonstrate corticosteroid resistance.
doi:10.33591/sfp.45.6.u1 fatcat:4y4vwg7r4nb6fhksjm5ynjmbem