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Continuous-flow biosynthesis of prostaglandin E2 (PGE2)
プロスタグランジンE2合成反応の連続化
1985
Nippon Nogeikagaku-kaishi
プロスタグランジンE2合成反応の連続化
Biosynthesis of PGE2 starting from arachidonate was investigated using a continuous-flow bioreactor with a hollow-fiber membrane of polyacrylonitrile. The merits of this system were that the production line was free of enzyme, PGE2 permeated easily through the membrane whereas arachidonate did not, and that operational factors, such as low substrate concentration, retention time, and methods of adding co-enzyme or co-factor, improved the production yield. This operation resulted in elongation
doi:10.1271/nogeikagaku1924.59.597
fatcat:bso5j45lpfgbhltwxwv7geqyk4