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Background The Investigation/Study/Assay (ISA) Metadata Framework is an established and widely used set of open source community specifications and software tools for enabling discovery, exchange, and publication of metadata from experiments in the life sciences. The original ISA software suite provided a set of user-facing Java tools for creating and manipulating the information structured in ISA-Tab—a now widely used tabular format. To make the ISA framework more accessible to machines anddoi:10.1093/gigascience/giab060 pmid:34528664 pmcid:PMC8444265 fatcat:emisaswturffta4b6bv7rlu5by