Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCPOGC) is a rare, highly malignant pancreatic exocrine neoplasm. Here, we report a case of UCPOGC in a 58-year-old man who presented with abdominal pain and weight loss. Abdomen computed tomography (CT) revealed a 5cm sized pancreatic body mass with peripheral enhancement. Endoscopic ultrasound (EUS)-guided biopsy of the mass suggested a solid-pseudopapillary tumor of the pancreas with a marked degenerative change.

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... tal pancreatectomy and splenectomy were performed. The size of the mass was 5.4 × 4.8 cm and the cut surface showed necrosis and hemorrhage. A definite diagnosis of UCPOGC was made using the histopathology and immunohistochemical findings. Korean J Pancreas Biliary Tract 2016;21(3):144-149 for pancytokeratin and chromogranin. These findings suggested solitary pseudopapillary tumor (SPT) with marked degenerative changes. Distal pancreatectomy and splenectomy were performed. Grossly, the resected mass was 5.4 × 4.8 cm in size and was composed of cystic and solid portions with necrosis and hemorrhage (Fig. 3A) . The tumor arose from the pancreas tail and it extended beyond the pancreas. Resection margin involvement was absent, but lymphatic, intravascular, perivascular, and perineural invasion were noted. Histologic study showed tumor cell components consisting of atypical neoplastic mononuclear cells admixed with nonneoplastic osteoclast-like giant cells (OGCs) on hematoxylin and eosin stain (H&E) (Fig. 3B ). The ductal adenocarcinoma component was also found in this case (Fig. 3C ). On the immunohistochemical stain, OGCs were strongly positive for CD68, which are indicative of the histiocytic origin (Fig. 4A ). Neoplastic mononuclear cells were positive for p53, but OGCs were negative for p53 (Fig. 4B) . Pancytokeratin was also focally positive, which suggests the ductal cell origin of the undifferentiated carcinoma with OGCs (Fig. 4C) . Vimentin was expressed in OGCs and neoplastic mononuclear cells (Fig. 4D) .