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As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely distributed protein domain families, and to record conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research. CDD offers both an archive of pre-computed domain annotations as well as live search services for bothdoi:10.1093/nar/gkz991 pmid:31777944 pmcid:PMC6943070 fatcat:uk6lpxuw7bfubpmruh4ociv2oa