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Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis
American Journal of Physiology - Gastrointestinal and Liver Physiology
Ulcerative colitis (UC) affects colonic motor function, but the mechanism responsible for this motor dysfunction is not well understood. We have shown that neurokinin A (NKA) may be an endogenous neurotransmitter mediating contraction of human sigmoid colonic circular muscle (HSCCM). To elucidate factors responsible for UC motor dysfunction, we examined the role of hydrogen peroxide (H 2O2) in the decrease of NKA-induced response of HSCCM. As previously demonstrated, NKA-induced contraction ordoi:10.1152/ajpgi.00414.2003 pmid:14670823 fatcat:234anervz5d6zfafqqtg5cuqbq