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CNS distribution, signalling properties and central effects of G-protein coupled receptor 4
2018
Neuropharmacology
Information on the distribution and biology of the G-protein coupled receptor 4 (GPR4) in the brain is limited. It is currently thought that GPR4 couples to G s proteins and may mediate central respiratory sensitivity to CO 2 . Using a knock-in mouse model, abundant GPR4 expression was detected in the cerebrovascular endothelium and neurones of dorsal raphe, retro-trapezoidal nucleus locus coeruleus and lateral septum. A similar distribution was confirmed using RNAscope in situ hybridisation.
doi:10.1016/j.neuropharm.2018.06.007
pmid:29894771
pmcid:PMC6063991
fatcat:lxcjh4nb7naflagnsk7aoqgnxa