Background:Diabetic nephropathy is the major cause for chronic renal failure (CRF) and proteinuria is an independent risk factor for end stage renal disease. Hence, early identification and quantification of proteinuria is of prime importance in the diagnosis and management. Method: The present study is a prospective observational study conducted amongst 50 diabetic subjects in Medicine department & IKDRC,Civil Hospital Ahmedabad.The study carried out during the period between July 2017 to

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... er 2019. All patients were treated as per standard treatment protocol. 24-hour urine protein and random urine protein to creatinine ratio (P:C) was determined. Result: Total 50(24 male &26 female) patients were studied. A strong correlation was found between 24 hours urine protein and protein- Creatinine ratio, especially in patient with eGFR >30 (CKD stage I to III) with coefficient of correlation of 0.973.However correlation weaken as the GFR worsens and is weakest in patients with stage 5 CKD Conclusion: The random urine Protein:Creatinine ratio predicts the amount of 24-hour urinary protein excretion with high accuracy.Hence it can be used as a faster substitute test for 24-hour urinary protein estimation.