A study to compare efficacy of various oral antifungals (Fluconazole, Terbinafine, Itraconazole) in treatment of Onychomycosis

Deval Vora, Bharti Bharti, Pooja Solanki, Anuj Kothari, Kamalini Meher
2014 Journal of Research in Medical and Dental Science  
Onychomycosis is accounting for upto 50% all nail disorders. It causes not only physical but also psychosocial and emotional distress to the patient. Treatment of the disease is far from satisfactory mainly due to high cost and long duration of therapy with poor patient compliance. Objective: to compare the efficacy of pulse therapy of oral Fluconazole, Terbinafine and Itraconazole. Methods: 90 patients of Onychomycosis were randomly divided into 3 treatment groups and followed up regularly.
more » ... ed up regularly. KOH smear and culture were done of all patients. Group A was given tablet Fluconazole 150 mg per week for 6 months in fingernail and 12 months in toenail onychomycosis. Group B was given tablet Terbinafine 250 mg and group C was given capsule Itraconazole 200 mg twice daily for 1 st 7 days/month for 3 or 4 months in finger or toe nails involvement respectively.
doi:10.5455/jrmds.2014249 fatcat:cr4vsjmzyngivcqqnpzntz66se